Conde Cecilia, Cáceres Alfredo
Laboratorio de Neurobiología Celular y Molecular, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Friuli 2434, 5016 Córdoba, Argentina.
Nat Rev Neurosci. 2009 May;10(5):319-32. doi: 10.1038/nrn2631.
During the past decade enormous advances have been made in our understanding of the basic molecular machinery that is involved in the development of neuronal polarity. Far from being mere structural elements, microtubules are emerging as key determinants of neuronal polarity. Here we review the current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites. These studies provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.
在过去十年里，我们对参与神经元极性发育的基本分子机制的理解取得了巨大进展。微管远非仅仅是结构元件，正逐渐成为神经元极性的关键决定因素。在此，我们综述目前对轴突和树突中微管组装、组织和动力学调控的理解。这些研究为微管在神经元发育中的功能及其对可塑性的潜在贡献提供了新的见解。
