铜绿假单胞菌外毒素S对p21ras及相关蛋白的ADP核糖基化作用
ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S.
作者信息
Coburn J, Gill D M
机构信息
Department of Molecular Biology and Microbiology, Tufts University Health Sciences Campus, Boston, Massachusetts 02111.
出版信息
Infect Immun. 1991 Nov;59(11):4259-62. doi: 10.1128/iai.59.11.4259-4262.1991.
Abstract
Pseudomonas aeruginosa exoenzyme S ADP-ribosylates p21ras and several related proteins. ADP-ribosylation of p21ras does not alter interactions with guanine nucleotides. The ras-related GTP-binding proteins, including Rab3, Rab4, Ral, Rap1A, and Rap2, are also substrates; given these results, we propose a model for the role of exoenzyme S in pathogenesis.
摘要
铜绿假单胞菌外毒素S可使p21ras及几种相关蛋白发生ADP核糖基化。p21ras的ADP核糖基化不会改变其与鸟嘌呤核苷酸的相互作用。包括Rab3、Rab4、Ral、Rap1A和Rap2在内的ras相关GTP结合蛋白也是外毒素S的作用底物；基于这些结果，我们提出了一个关于外毒素S在发病机制中作用的模型。
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