瞬时弹性成像预测结肠癌患者奥沙利铂相关肝损伤的初步分析
Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis.
作者信息
Oki Eiji, Kakeji Yoshihiro, Taketomi Akinobu, Yamashita Yoichi, Ohgaki Kippei, Harada Noboru, Iguchi Tomohiro, Shibahara Kotaro, Sadanaga Noriaki, Morita Masaru, Maehara Yoshihiko
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
出版信息
J Gastrointest Cancer. 2008;39(1-4):82-5. doi: 10.1007/s12029-009-9063-1. Epub 2009 Apr 18.
OBJECTIVE
The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult.
METHODS
Elastography (Fibroscan) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment.
RESULTS
A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically.
CONCLUSION
Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.
目的
自从包括奥沙利铂在内的新化疗方案研发出来后，晚期结肠癌的预后在过去十年里有了显著改善。然而，化疗后可能会出现奥沙利铂诱导的肝损伤以及特征性的肝脏止血状态。对这类肝损伤的评估往往很困难。
方法
使用弹性成像（Fibroscan）评估5例患者在接受氟尿嘧啶、亚叶酸钙和奥沙利铂联合方案（FOLFOX）治疗前后的肝损伤情况。
结果
化疗后48小时内观察到肝脏硬度有明显变化，大多数病例在2周后肝脏硬度恢复正常。5例患者中，1例患者在接受FOLFOX治疗后出现异常升高，且该患者经病理检查显示有肝损伤。
结论
弹性成像是评估FOLFOX治疗后肝损伤的良好工具。
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