细胞因子对小鼠利什曼病的调节作用：白细胞介素4不足以介导抗性C57BL/6小鼠的进行性疾病。
Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.
作者信息
Sadick M D, Street N, Mosmann T R, Locksley R M
机构信息
Department of Medicine, University of California, San Francisco 94143.
出版信息
Infect Immun. 1991 Dec;59(12):4710-4. doi: 10.1128/iai.59.12.4710-4714.1991.
Abstract
Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.
摘要
在感染硕大利什曼原虫时中和白细胞介素4（IL-4）可使易感的BALB/c小鼠痊愈。然而，重组IL-4对具有抗性的C57BL/6小鼠的硕大利什曼原虫感染进程几乎没有影响，巴西日圆线虫共感染也没有影响，尽管内源性IL-4水平显著升高。
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