Santiago H C, Oliveira M A, Bambirra E A, Faria A M, Afonso L C, Vieira L Q, Gazzinelli R T
Department of Biochemistry and Immunology-ICB, Federal University of Minas Gerais, 31270-910 Belo Horizonte, Brazil.
Infect Immun. 1999 Sep;67(9):4939-44. doi: 10.1128/IAI.67.9.4939-4944.1999.
Lesion size, cellular infiltration, and tissue parasitism in the footpads of BALB/c mice infected with Leishmania major were all dramatically inhibited during acute but not chronic infection with Toxoplasma gondii. Similarly, acute but not chronic toxoplasmosis at the time of infection with L. major had a strong inhibitory effect on development of acquired immune responses mediated by Th2 lymphocytes. In contrast, no major changes in Leishmania-specific Th1-mediated responses were observed in mice coinfected with T. gondii.
感染硕大利什曼原虫的BALB/c小鼠足垫中的病变大小、细胞浸润和组织寄生现象，在急性感染刚地弓形虫期间均受到显著抑制，但慢性感染时则未受抑制。同样，在感染硕大利什曼原虫时发生的急性而非慢性弓形虫病，对由Th2淋巴细胞介导的获得性免疫反应的发展具有强烈的抑制作用。相比之下，在同时感染弓形虫的小鼠中，未观察到利什曼原虫特异性Th1介导反应有重大变化。
