Kristensen K, Strevens H, Lindström V, Grubb A, Wide-Swensson D
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
Scand J Clin Lab Invest. 2008;68(7):649-53. doi: 10.1080/00365510802007804.
To study concentration gradients of the low molecular mass proteins, beta2-microglobulin, cystatin C and beta-trace protein, between the uterine and ante-cubital veins, the umbilical artery and vein and in the amniotic fluid compartment.
The study comprised 27 healthy women with uncomplicated pregnancies undergoing caesarean section at term. Samples were collected simultaneously and paired t-tests were used to compare mean plasma concentrations.
There was no significant concentration gradient in the plasma levels of beta2-microglobulin, cystatin C or beta-trace protein between the uterine and antecubital veins. There were no correlations between the protein levels in the compartments.
The utero-placental unit does not contribute significantly to the maternal levels of beta2-microglobulin, cystatin C and beta-trace protein in normal pregnancy, and the proteins are not likely to be transferred across the placental barrier.
研究低分子量蛋白质β2-微球蛋白、胱抑素C和β-微量蛋白在子宫静脉和肘前静脉、脐动脉和静脉以及羊水腔之间的浓度梯度。
该研究包括27名足月行剖宫产的无并发症妊娠健康女性。同时采集样本，并使用配对t检验比较平均血浆浓度。
子宫静脉和肘前静脉之间β2-微球蛋白、胱抑素C或β-微量蛋白的血浆水平无显著浓度梯度。各腔室中蛋白质水平之间无相关性。
在正常妊娠中，子宫-胎盘单位对母体β2-微球蛋白、胱抑素C和β-微量蛋白水平的贡献不大，这些蛋白质不太可能穿过胎盘屏障。
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