Okada Kana, Okaichi Hiroshige
Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Japan.
Behav Brain Res. 2009 Jun 8;200(1):181-91. doi: 10.1016/j.bbr.2009.01.011.
We investigated the roles of the hippocampal subregions and intrahippocampal networks in effecting spatial reference and working processes. The results showed that the dentate gyrus plays a key role in encoding both types of spatial memory. Lesions in the dentate gyrus caused severe impairment in the acquisition of the Morris water maze and delayed matching-to-place tasks as compared to those in the other hippocampal subregions (Exp. 1). Further, there was functional cooperation between CA3 and CA1 via the Schaffer collaterals and the hippocampal commissure in the performance of both types of spatial memory tasks. Among the rats with intact hippocampal commissure, those with both contralateral and ipsilateral CA1/CA3 lesions showed a similar performance (Exp. 2A); however, among the rats with transected hippocampal commissure, those with the contralateral CA1/CA3 lesions showed a more disruptive performance than the rats with the ipsilateral CA1/CA3 lesions (Exp. 2B). This study suggests that the hippocampus is the functional unit for spatial reference and working memory processes, including differential functions and functional cooperation among the hippocampal subregions.
我们研究了海马亚区和海马内神经网络在空间参考和工作过程中的作用。结果表明，齿状回在两种类型的空间记忆编码中起关键作用。与其他海马亚区相比，齿状回损伤导致在莫里斯水迷宫和延迟位置匹配任务的获取中出现严重损伤（实验1）。此外，在执行两种类型的空间记忆任务时，CA3和CA1之间通过谢弗侧支和海马连合存在功能协作。在海马连合完整的大鼠中，双侧CA1/CA3损伤的大鼠与同侧CA1/CA3损伤的大鼠表现相似（实验2A）；然而，在海马连合横断的大鼠中，对侧CA1/CA3损伤的大鼠比同侧CA1/CA3损伤的大鼠表现出更严重的破坏（实验2B）。这项研究表明，海马是空间参考和工作记忆过程的功能单元，包括海马亚区之间的不同功能和功能协作。
