Rother K, Hänsch G M, Rauterberg E W
Institute of Immunology, University of Heidelberg, FRG.
Int Arch Allergy Appl Immunol. 1991;94(1-4):23-37. doi: 10.1159/000235320.
The C5b-9 complex has a dual role as a factor involved in the initiation of nephritides and in the progress to chronicity and sclerosis. The unique pathophysiology of the membrane attack complex, distinct from other mediators, is its independence from specific receptors. It inserted in any membrane lipid bilayer tested so far.
C5b - 9复合物具有双重作用,既是参与肾炎起始过程的一个因素,也是促使病情发展至慢性化和硬化的因素。膜攻击复合物独特的病理生理学不同于其他介质,在于它不依赖特定受体。迄今为止,它可插入任何测试过的膜脂质双层中。