Rus H G, Niculescu F, Nanulescu M, Cristea A, Florescu P
Clin Exp Immunol. 1986 Jul;65(1):66-72.
Kidney biopsies were obtained in 28 children with glomerular diseases and studied using indirect immunofluorescence and immunoperoxidase for IgG, IgA, IgM, C1q, C3c, C4, fibrinogen and the neoantigens of the terminal C5b-9 complement complex. C5b-9 deposits were detected in glomeruli of 14, in tubules of eight and in vessels of 12 cases. Patients with C5b-9 deposits fared worse than those without such deposits, even with the same histopathological type of glomerulonephritis. The C5b-9 complex suggests an in situ complement activation.
对28例肾小球疾病患儿进行肾活检，采用间接免疫荧光和免疫过氧化物酶法检测IgG、IgA、IgM、C1q、C3c、C4、纤维蛋白原及终末C5b - 9补体复合物的新抗原。在14例患者的肾小球、8例患者的肾小管和12例患者的血管中检测到C5b - 9沉积。即使肾小球肾炎组织病理学类型相同，有C5b - 9沉积的患者病情比无此类沉积的患者更差。C5b - 9复合物提示补体原位激活。
