控制乳腺癌中E-钙黏蛋白表达的分子机制。
Molecular mechanisms controlling E-cadherin expression in breast cancer.
作者信息
Baranwal Somesh, Alahari Suresh K
机构信息
Department of Biochemistry and Molecular Biology, LSU Health Science Center, New Orleans, LA 70112, USA.
出版信息
Biochem Biophys Res Commun. 2009 Jun 19;384(1):6-11. doi: 10.1016/j.bbrc.2009.04.051. Epub 2009 Apr 18.
Abstract
Disruption of cell-cell adhesion, which is essential for the maintenance of epithelial plasticity and is mediated by a class of proteins called cadherins, is an initial event in the progression of cancer. Cadherins are Ca(2+)-dependent transmembrane proteins that are associated with actin via other cytoplasmic proteins. Disruption of cell-cell adhesion during cancer progression is an important event during cancer initiation and metastasis. E-cadherin, one of the most widely studied tumor suppressors in breast cancer, belongs to a family of calcium-dependent cell adhesion molecules. Various signaling molecules and transcription factors regulate the expression of E-cadherin. Loss of E-cadherin has been reported to induce epithelial-mesenchymal transition in several cancers. This review highlights recent advances in defining the mechanisms that regulate E-cadherin expression in breast cancer.
摘要
细胞间黏附的破坏是癌症进展过程中的一个初始事件，它对于维持上皮可塑性至关重要，且由一类称为钙黏蛋白的蛋白质介导。钙黏蛋白是依赖钙离子的跨膜蛋白，通过其他细胞质蛋白与肌动蛋白相关联。癌症进展过程中细胞间黏附的破坏是癌症起始和转移过程中的一个重要事件。E-钙黏蛋白是乳腺癌中研究最广泛的肿瘤抑制因子之一，属于钙依赖性细胞黏附分子家族。多种信号分子和转录因子调节E-钙黏蛋白的表达。据报道，E-钙黏蛋白的缺失在几种癌症中可诱导上皮-间质转化。本综述重点介绍了在确定调节乳腺癌中E-钙黏蛋白表达的机制方面的最新进展。
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