1型单纯疱疹病毒免疫对小鼠抵御2型单纯疱疹病毒急性和潜伏感染的效果。
Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice.
作者信息
McKendall R R
出版信息
Infect Immun. 1977 May;16(2):717-9. doi: 10.1128/iai.16.2.717-719.1977.
Abstract
ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.
摘要
将1型单纯疱疹病毒（HSV-1）免疫ICR小鼠，随后通过足垫接种用HSV-2攻击。观察免疫动物和年龄匹配的未免疫对照，以了解由HSV-2攻击导致的上行性神经疾病和脊髓神经节的潜伏感染情况。对照动物急性和潜伏感染的发生率为78%，而免疫小鼠的发生率为1.7%。数据表明，对HSV-1的免疫可预防HSV-2的急性和潜伏感染。
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