McKendall R R
Infect Immun. 1977 May;16(2):717-9. doi: 10.1128/iai.16.2.717-719.1977.
ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.
将1型单纯疱疹病毒(HSV-1)免疫ICR小鼠,随后通过足垫接种用HSV-2攻击。观察免疫动物和年龄匹配的未免疫对照,以了解由HSV-2攻击导致的上行性神经疾病和脊髓神经节的潜伏感染情况。对照动物急性和潜伏感染的发生率为78%,而免疫小鼠的发生率为1.7%。数据表明,对HSV-1的免疫可预防HSV-2的急性和潜伏感染。