Lankiewicz Silke, Zimmermann Silke, Hollmann Christiane, Hillemann Tina, Greten Tim F
AdnaGen AG, Ostpassage 7, D-30853 Langenhagen, Germany.
Mol Oncol. 2008 Dec;2(4):349-55. doi: 10.1016/j.molonc.2008.09.001. Epub 2008 Sep 16.
Circulating tumour cells (CTC) can be traced in patients with different types of cancer. The aim of this study was to detect CTC in patients with advanced colorectal cancer and whether CTC are still detectable after systemic chemotherapy. Blood from 34 patients with advanced colorectal cancer was analysed for the presence of CTC before chemotherapy was given and after 3 months. Eleven patients demonstrated a tumour remission after chemotherapy. In 6 cases CTC were detectable before but not after initiation of chemotherapy. Ten patients demonstrated a progression. In 5 cases CTC were detected before and after chemotherapy. Our data suggest that the detection of CTC will help to identify patients responding to chemotherapy or with a risk of a therapy failure.
在不同类型癌症患者中可追踪到循环肿瘤细胞(CTC)。本研究的目的是检测晚期结直肠癌患者的CTC,以及全身化疗后是否仍可检测到CTC。对34例晚期结直肠癌患者化疗前及化疗3个月后的血液进行CTC检测。11例患者化疗后肿瘤缓解。6例患者化疗前可检测到CTC,但化疗开始后未检测到。10例患者病情进展。5例患者化疗前后均检测到CTC。我们的数据表明,检测CTC将有助于识别对化疗有反应或有治疗失败风险的患者。