Shi Pujiang, Zuo Yi, Zou Qin, Shen Juan, Zhang Li, Li Yubao, Morsi Yos S
The Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Int J Pharm. 2009 Jun 22;375(1-2):67-74. doi: 10.1016/j.ijpharm.2009.04.016. Epub 2009 Apr 19.
In this article, to discover an innovative drug release system, ciprofloxacin hydrochloride-loaded blending films of chitosan (CS)/ethyl cellulose (EC) microspheres were prepared. Two steps were adopted in the film forming process. The first was formation of the drug-loaded EC microspheres in CS solution by solvent remove/solvent evaporation methods; then, the composite films were made by casting and solvent evaporation. The results were that the drug-loaded round EC microspheres dispersed asymmetrically in the CS films and largely improved the release time. Moreover, the drug-loaded blending film containing 0.5 g EC microspheres prepared at 90 degrees C showed highlighted extended release property. The drug was stable in the blending films, which expressed good cytocompatibility proved by MTT test. The film should be a promising carrier for controlled and extended drug release system in pharmaceutical applications.
在本文中，为了发现一种创新的药物释放系统，制备了载有盐酸环丙沙星的壳聚糖（CS）/乙基纤维素（EC）微球共混膜。成膜过程采用两步法。第一步是通过溶剂去除/溶剂蒸发法在CS溶液中形成载药EC微球；然后，通过流延和溶剂蒸发制备复合膜。结果表明，载药的圆形EC微球不对称地分散在CS膜中，大大延长了释放时间。此外，在90℃制备的含有0.5 g EC微球的载药共混膜表现出突出的缓释性能。药物在共混膜中稳定，MTT试验证明其具有良好的细胞相容性。该膜有望成为药物应用中控制和延长药物释放系统的载体。
