Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
J Mater Sci Mater Med. 2012 Mar;23(3):687-95. doi: 10.1007/s10856-012-4554-1.
The present study was aimed to develop chitosan-EDTA films and evaluate their physico-chemical and mechanical properties. The physical properties suggested lowest swelling, volume and volume index of films prepared by employing equal weight of chitosan (CH) and EDTA (1.5% w/v). The CH:EDTA film (1:l, on weight basis) showed minimum contact angle, work of adhesion and high negative spreading coefficient indicating lipophilic behavior of film. Further, the FTIR and DSC analysis suggested maximum crosslinking density in film prepared with equal proportion of CH and EDTA. The mechanical properties explored using texture analyzer revealed increasing the proportions of EDTA rendered the films more flexible and decreased their hardness. Furthermore, in vitro permeation of 5-FU and mesalamine with different solubilities showed minimum permeation across CH–EDTA (1:1) film, indicating high crosslinking density that decreased void space inside the film. Hence, the CH–EDTA conjugate could be considered to be possess great potential for various pharmaceutical applications such as film based delivery systems, controlled and sustained delivery systems etc.
本研究旨在开发壳聚糖-EDTA 薄膜，并评估其物理化学和机械性能。物理性能表明，当壳聚糖（CH）和 EDTA 的重量相等（1.5% w/v）时，制备的薄膜具有最低的溶胀度、体积和体积指数。CH:EDTA 薄膜（1:1，按重量计）表现出最小的接触角、粘附功和高负扩展系数，表明薄膜具有亲脂性。此外，FTIR 和 DSC 分析表明，在 CH 和 EDTA 等比例制备的薄膜中具有最大的交联密度。使用质构分析仪探索的机械性能表明，增加 EDTA 的比例使薄膜更具柔韧性，并降低其硬度。此外，不同溶解度的 5-FU 和美沙拉嗪的体外渗透实验表明，CH-EDTA（1:1）薄膜的渗透量最小，表明交联密度高，降低了薄膜内部的空隙空间。因此，CH-EDTA 缀合物可能具有很大的潜力，可用于各种制药应用，如基于薄膜的给药系统、控制和持续释放系统等。
