Boo N Y, Lim S M, Koh K T, Lau K F, Ravindran J
Department of Paediatrics, Clincial School, International Medical University, Malaysia.
Med J Malaysia. 2008 Oct;63(4):306-10.
This study aimed to identify the risk factors which were significantly associated with low birth weight (LBW, <2500 g) infants among the Malaysian population. This was a case-control study carried out at the Tuanku Jaafar Hospital, Seremban, Malaysia over a five-month period. Cases were all infants born with birth weight less than 2500 g. Control infant were selected with the help a random sampling table from among infants with birth weight of > or =2500 g born on the same day in the hospital. Of 3341 livebirths delivered in the hospital, 422 (12.6%) were LBW infants. Logistic regression analysis showed that, after controlling for various potential confounders, the only significant risk factors associated with infants of LBW were gestational age (adjusted odds ratio (OR)=0.6, 95% C.I.: 0.5, 0.6; < 0.0001), maternal pre-pregnancy weight (adjusted OR = 0.97, 95% C.I.: 0.95, 0.99; p < 0.0001), nulliparity (adjusted OR = 3.4, 95% C.I.: 2.2, 5.1; p < 0.0001), previous history of LBW infants (adjusted OR = 2.3, 95% C.I.: 1.4, 3.8; p=0.001) and PIH during current pregnancy (adjusted OR=3.3, 95% C.I.: 1.6, 6.6; p = 0.001). A number of potentially preventable or treatable risk factors were identified to be associated with LBW infants in Malaysia.
本研究旨在确定马来西亚人群中与低出生体重（LBW，<2500克）婴儿显著相关的风险因素。这是一项在马来西亚芙蓉市端姑查法医院进行的为期五个月的病例对照研究。病例为所有出生体重低于2500克的婴儿。对照婴儿是通过随机抽样表从同一天在该医院出生、出生体重≥2500克的婴儿中选取的。在该医院分娩的3341例活产中，422例（12.6%）为低出生体重婴儿。逻辑回归分析显示，在控制了各种潜在混杂因素后，与低出生体重婴儿相关的唯一显著风险因素为孕周（调整比值比（OR）=0.6，95%置信区间：0.5，0.6；<0.0001）、母亲孕前体重（调整OR = 0.97，95%置信区间：0.95，0.99；p < 0.0001）、初产（调整OR = 3.4，95%置信区间：2.2，5.1；p < 0.0001）、既往低出生体重婴儿史（调整OR = 2.3，95%置信区间：1.4，3.8；p = 0.001）以及本次孕期的妊娠期高血压疾病（调整OR = 3.3，95%置信区间：1.6，6.6；p = 0.001）。研究确定了一些在马来西亚与低出生体重婴儿相关的、具有潜在可预防性或可治疗性的风险因素。
