Fu K K, Lam K N
Department of Radiation Oncology, University of California, San Francisco 94143.
Int J Radiat Oncol Biol Phys. 1991 Nov;21(6):1523-8. doi: 10.1016/0360-3016(91)90328-2.
The early and late effects of combined mitomycin C and continuous low-dose-rate irradiation (CLDRI) on the skin and soft tissues were studied in the C3Hf/SED mice. Localized CLDRI of the hind leg at 0.028 Gy/min with and without mitomycin C was delivered using a 137Cs laboratory irradiator. Mitomycin C at 6 mg/kg was given by continuous infusion through intraperitoneally implanted osmotic mini-pumps during CLDRI. Acute skin reaction was scored from days 13 to 30 and late skin contraction and leg contracture were measured at days 90, 180, 270, and 360 after treatment. Mitomycin C increased the early skin reaction following CLDRI; at a dose of 60 Gy, the dose effect factor was approximately 1.1. However, there was no significant enhancement of late skin contraction or leg contracture by mitomycin C. Our results suggest that mitomycin C can be combined with low-dose-rate brachytherapy without a significant increase in early or late damage to the skin and soft tissues.
在C3Hf/SED小鼠中研究了丝裂霉素C与连续低剂量率照射（CLDRI）联合应用对皮肤和软组织的早期和晚期效应。使用137Cs实验室辐照器对后肢进行局部CLDRI，剂量率为0.028 Gy/min，分别给予和不给予丝裂霉素C。在CLDRI期间，通过腹腔内植入的渗透微型泵连续输注6 mg/kg的丝裂霉素C。在治疗后第13至30天对急性皮肤反应进行评分，并在治疗后第90、180、270和360天测量晚期皮肤收缩和腿部挛缩情况。丝裂霉素C增加了CLDRI后的早期皮肤反应；在60 Gy剂量时，剂量效应因子约为1.1。然而，丝裂霉素C并未显著增强晚期皮肤收缩或腿部挛缩。我们的结果表明，丝裂霉素C可与低剂量率近距离放射治疗联合应用，而不会显著增加皮肤和软组织的早期或晚期损伤。
