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特应性皮炎肥大细胞中神经生长因子 3 的高丰度。

High abundances of neurotrophin 3 in atopic dermatitis mast cell.

机构信息

Institute of Occupational Medicine, Charité - Universitätsmedizin Berlin, Free University and Humboldt University, D-14195 Berlin, Germany.

出版信息

J Occup Med Toxicol. 2009 Apr 22;4:8. doi: 10.1186/1745-6673-4-8.

DOI:10.1186/1745-6673-4-8
PMID:19386090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2680865/
Abstract

BACKGROUND

Neurotrophin 3 (NT-3) is a member of the neurotrophin family, a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases. Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far.

OBJECTIVE

Characterize NT-3 on a transcriptional and translational level in individuals with atopic dermatitis with special focus on mast cells.

METHODS

To meet this objective NT-3 levels in the serum of AD patients were measured, the effect of NT-3 on keratinocytes was evaluated and the gene expression and regulation assessed using ELISA, immunohistochemistry and RNA quantification.

RESULTS

Systemic levels of NT-3 were found to be higher in individuals with AD as compared to healthy controls. A distinct genetic expression was found in the various cells of the skin. In lesional mast cells of individuals with atopic dermatitis an increased amount of NT-3 was apparent. Functional in vitro experiments demonstrated that NT-3 stimulation led to a suppression of IL-8 secretion by HaCat cells.

CONCLUSION

These findings could imply a role for NT-3 in the pathogenesis of allergic skin diseases.

摘要

背景

神经生长因子 3（NT-3）是神经生长因子家族的一员，该家族的一组相关蛋白被认为可以调节过敏疾病中的神经免疫相互作用。迄今为止，尚未详细描述它们在特应性皮炎中肥大细胞前体募集中的细胞来源和作用。

目的

在特应性皮炎患者中从转录和翻译水平上对 NT-3 进行特征描述，特别关注肥大细胞。

方法

为了实现这一目标，测量了 AD 患者血清中的 NT-3 水平，评估了 NT-3 对角质形成细胞的作用，并使用 ELISA、免疫组织化学和 RNA 定量评估了基因表达和调控。

结果

与健康对照组相比，AD 个体的 NT-3 系统水平升高。在皮肤的各种细胞中发现了明显的遗传表达。在特应性皮炎患者的病变肥大细胞中，NT-3 的含量明显增加。体外功能实验表明，NT-3 刺激导致 HaCat 细胞分泌的 IL-8 减少。

结论

这些发现可能意味着 NT-3 在过敏性皮肤疾病的发病机制中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/1319f497b761/1745-6673-4-8-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/45fa60762532/1745-6673-4-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/3ee8c3c35940/1745-6673-4-8-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/def3b396e442/1745-6673-4-8-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/1319f497b761/1745-6673-4-8-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/45fa60762532/1745-6673-4-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/3ee8c3c35940/1745-6673-4-8-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/def3b396e442/1745-6673-4-8-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73e/2680865/1319f497b761/1745-6673-4-8-4.jpg

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Neurosci Lett. 2007 Mar 19;415(1):87-9. doi: 10.1016/j.neulet.2007.01.002. Epub 2007 Jan 17.
2
Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo.利用肥大细胞敲入小鼠分析肥大细胞在体内过敏反应中的作用。
Chem Immunol Allergy. 2005;87:179-197. doi: 10.1159/000087644.
3
Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood.
J Am Acad Dermatol. 2023 May;88(5):1083-1093. doi: 10.1016/j.jaad.2022.12.050. Epub 2023 Feb 10.
4
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J Am Acad Dermatol. 2022 Feb;86(2):322-330. doi: 10.1016/j.jaad.2021.07.035. Epub 2021 Jul 30.
5
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Front Immunol. 2021 Apr 12;12:660203. doi: 10.3389/fimmu.2021.660203. eCollection 2021.
6
Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma.神经炎症基因表达模式在变应性鼻炎和特应性皮炎之间相似，但与特应性哮喘不同。
Biomed Res Int. 2020 Jun 10;2020:7196981. doi: 10.1155/2020/7196981. eCollection 2020.
7
p75 Neurotrophin Receptor in the Skin: Beyond Its Neurotrophic Function.皮肤中的p75神经营养因子受体：超越其神经营养功能
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8
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9
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6
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8
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9
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