Adhikari Anirban, Chen Zhijian J
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Dev Cell. 2009 Apr;16(4):485-6. doi: 10.1016/j.devcel.2009.04.001.
Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).
通过泛素不同赖氨酸连接的多聚泛素链可能发挥蛋白酶体依赖性和非依赖性功能。在最近一期的《细胞》杂志上，徐等人利用定量蛋白质组学分析酵母中的多聚泛素连接。他们发现，除赖氨酸-63外，通过泛素所有赖氨酸的连接都能在体内靶向蛋白酶体降解，并且赖氨酸-11多聚泛素化对内质网相关降解（ERAD）很重要。
