Porta Miquel, Gasull Magda, Puigdomènech Elisa, Rodríguez-Sanz Maica, Pumarega José, Rebato Carolina, Borrell Carme
Clinical and Molecular Epidemiology of Cancer Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.
Chemosphere. 2009 Jun;76(2):216-25. doi: 10.1016/j.chemosphere.2009.03.030. Epub 2009 Apr 21.
Little is known about factors affecting participation in population-based biomonitoring studies. We analyzed socioeconomic factors influencing participation in the Barcelona Health Survey (BHS) study on the distribution of serum concentrations of persistent organic pollutants (POPs).
After completing the BHS personal interview at home participants aged >or=15 years were invited to donate blood. Conducted on a different date and location, the POPs study included additional questions, blood extraction, and a brief physical examination. Factors influencing participation were analyzed by logistic regression.
Of 523 BHS participants that we contacted to participate in the study, 231 (44%) participated; they were broadly representative of the city population regarding sex, birth place, body mass index (BMI), employment status and occupational social class. Participants in the POPs study had higher educational level and family income. Controlling for confounders, participation was slightly higher among women than men (odds ratio [OR]=1.38, p=0.02), and lower among the youngest and oldest subjects (p=0.002), with a strong and monotonic trend of increasing participation with increasing educational level (p<0.001) (OR for university level vs. no studies=4.58, 95% CI: 2.3-9.3).
Although participation was somewhat low, participants were similar to the city population regarding sex, BMI, birth place, employment, and occupational social class. Health surveys that integrate environmental biomarkers should invest specific resources to encourage participation of the youngest and oldest individuals, and of those with more disadvantaged socioeconomic position (particularly, citizens with lowest education).
关于影响参与基于人群的生物监测研究的因素,我们了解甚少。我们分析了影响参与巴塞罗那健康调查(BHS)中持久性有机污染物(POPs)血清浓度分布研究的社会经济因素。
在家中完成BHS个人访谈后,邀请年龄≥15岁的参与者献血。POPs研究在不同日期和地点进行,包括额外的问题、血液采集和简短的体格检查。通过逻辑回归分析影响参与的因素。
在我们联系参与研究的523名BHS参与者中,231名(44%)参与了研究;他们在性别、出生地、体重指数(BMI)、就业状况和职业社会阶层方面广泛代表了城市人口。POPs研究的参与者教育水平和家庭收入较高。在控制混杂因素后,女性的参与率略高于男性(优势比[OR]=1.38,p=0.02),最年轻和最年长的参与者参与率较低(p=0.002),随着教育水平的提高,参与率呈强烈且单调的上升趋势(p<0.001)(大学学历与未接受教育者相比的OR=4.58,95%CI:2.3 - 9.3)。
尽管参与率有所偏低,但参与者在性别、BMI、出生地、就业和职业社会阶层方面与城市人口相似。整合环境生物标志物的健康调查应投入特定资源,以鼓励最年轻和最年长的个体以及社会经济地位较为不利的人群(特别是受教育程度最低的公民)参与。