Hospital del Mar Research Institute- IMIM, Barcelona, Catalonia, Spain.
Sci Total Environ. 2012 Apr 15;423:151-61. doi: 10.1016/j.scitotenv.2012.02.001. Epub 2012 Mar 6.
POP biomonitoring programs are useful for exposure assessment, to analyze patterns, and to evaluate policies. However, population-representative surveys are scarce and heterogeneous. Reports on time trends in representative samples using the same methods are rare.
To analyze the distribution of serum concentrations of 19 POPs in the general population of Barcelona city in 2006, and to compare it with the distribution in 2002.
231 participants in the Barcelona Health Survey were interviewed face-to-face, gave blood, and underwent a physical exam. Density plots ("POP Geoffrey Rose curves") were used to represent the full population distribution of each compound.
Eight POPs were each detected in >80% of the study subjects: p,p'-DDT, p,p'-DDE, PCB congeners 118, 138, 153 and 180, HCB and β-HCH. The minimum number of POPs detected in one person was 5, and 72% of the population accumulated ≥ 10 compounds. p,p'-DDE and HCB showed the highest concentrations (median=219 and 109 ng/g lipid, respectively). Concentrations decreased by 34-56% from 2002 to 2006. The decrease was similar in women and men, and in all age groups/birth cohorts. It was larger with increasing BMI; for p,p'-DDT, HCB and β-HCH the decrease in obese individuals was 31-44 percentage points larger than in subjects with normal weight. The distribution of POP concentrations was always switched towards higher values in women than men. POP levels also differed significantly by age, body mass index, weight gain, birth place and social class, but not by parity and breastfeeding. The two younger cohorts had a higher DDT/DDE ratio than the oldest cohort.
Although human POP contamination remains common in the city of Barcelona, concentrations decreased significantly in 4years. Our approach suggests innovative ways to conceive, analyze and present results for other monitoring programs.
POP 生物监测计划对于暴露评估、分析模式和评估政策非常有用。然而，具有代表性的人口调查非常稀缺且存在差异。使用相同方法报告代表性样本中的时间趋势的报告很少。
分析 2006 年巴塞罗那市普通人群血清中 19 种持久性有机污染物（POPs）的浓度分布，并将其与 2002 年的分布进行比较。
对巴塞罗那健康调查中的 231 名参与者进行面对面访谈、采血和体检。密度图（“POP Geoffrey Rose 曲线”）用于表示每种化合物的全人群分布。
有 8 种 POPs 分别在 80%以上的研究对象中被检测到：p,p'-DDT、p,p'-DDE、PCB 同系物 118、138、153 和 180、HCB 和β-HCH。一个人检测到的最少 POP 数量为 5 种，72%的人群积累了≥10 种化合物。p,p'-DDE 和 HCB 的浓度最高（中位数分别为 219 和 109ng/g 脂质）。2002 年至 2006 年，浓度下降了 34-56%。女性和男性以及所有年龄组/出生队列的下降幅度相似。随着 BMI 的增加而增加；对于 p,p'-DDT、HCB 和β-HCH，肥胖个体的下降幅度比体重正常个体大 31-44 个百分点。POP 浓度的分布始终向女性高于男性的方向转变。POP 水平也因年龄、体重指数、体重增加、出生地点和社会阶层而有显著差异，但与产次和母乳喂养无关。两个较年轻的队列的 DDT/DDE 比值高于最年长的队列。
尽管人类 POP 污染在巴塞罗那市仍然很常见，但在 4 年内浓度显著下降。我们的方法为其他监测计划的构思、分析和呈现结果提供了创新的思路。
