Ghods-Sharifi Sarvin, St Onge Jennifer R, Floresco Stan B
Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
J Neurosci. 2009 Apr 22;29(16):5251-9. doi: 10.1523/JNEUROSCI.0315-09.2009.
Impairments in decision making about risks and rewards have been observed in patients with amygdala damage. Similarly, lesions of the basolateral amygdala (BLA) in rodents disrupts cost/benefit decision making, reducing preference for larger rewards obtainable after a delay or considerable physical effort. We assessed the effects of inactivation of the BLA on risk- and effort-based decision making, using discounting tasks conducted in an operant chamber. Separate groups of rats were trained on either a risk- or effort-discounting task, consisting of four blocks of 10 free-choice trials. Selection of one lever always delivered a smaller reward (one or two pellets), whereas responding on the other delivered a larger, four pellet reward. For risk discounting, the probability of receiving the larger reward decreased across trial blocks (100-12.5%), whereas on the effort task, the larger reward was delivered after a ratio of presses that increased across blocks (2-20). Infusions of GABA agonists baclofen/muscimol into the BLA disrupted risk discounting, inducing a risk-averse pattern of choice, and increased response latencies and trial omissions, most prominently during trial blocks that provided the greatest uncertainty about the most beneficial course of action. Similar inactivations also increased effort discounting, reducing the preference for larger yet more costly rewards, even when the relative delays to reward delivery were equalized across response options. These findings point to a fundamental role for the BLA in different forms of cost/benefit decision making, facilitating an organism's ability to overcome a variety of costs (work, uncertainty, delays) to promote actions that may yield larger rewards.
杏仁核损伤的患者已被观察到在风险和回报决策方面存在障碍。同样,啮齿动物基底外侧杏仁核(BLA)的损伤会扰乱成本/收益决策,降低对延迟后或需要付出相当体力才能获得的更大奖励的偏好。我们使用在操作箱中进行的折扣任务,评估了BLA失活对基于风险和努力的决策的影响。将单独的几组大鼠分别训练进行风险折扣任务或努力折扣任务,每个任务由四个包含10次自由选择试验的组块组成。选择一个杠杆总是会获得较小的奖励(一或两颗食丸),而对另一个杠杆做出反应则会获得较大的、四颗食丸的奖励。对于风险折扣任务,获得较大奖励的概率在各个试验组块中逐渐降低(100%-12.5%),而在努力任务中,较大奖励是在按压次数比例逐渐增加的情况下(2-20)发放的。向BLA内注射GABA激动剂巴氯芬/蝇蕈醇会扰乱风险折扣,诱导出规避风险的选择模式,并增加反应潜伏期和试验遗漏,在提供关于最有利行动方案最大不确定性的试验组块中最为明显。类似的失活也会增加努力折扣,降低对更大但成本更高的奖励的偏好,即使在不同反应选项的奖励发放相对延迟相等的情况下也是如此。这些发现表明BLA在不同形式的成本/收益决策中具有基本作用,有助于生物体克服各种成本(工作、不确定性、延迟)以促进可能产生更大奖励的行动的能力。