Krueger Thilo, Westenfeld Ralf, Ketteler Markus, Schurgers Leon J, Floege Jürgen
Division of Nephrology and Clinical Immunology, University Hospital, RWTH University of Aachen, Germany.
Kidney Int. 2009 Jul;76(1):18-22. doi: 10.1038/ki.2009.126. Epub 2009 Apr 22.
The purpose of this review is to summarize currently available evidence implicating vitamin K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification. In doing so, we try to provide a rationale for an interventional clinical study testing whether vitamin K supplementation can retard VC or even affect cardiovascular mortality in chronic kidney disease patients. Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population.
本综述的目的是总结目前有关维生素K参与血管钙化（VC），尤其是动脉中层钙化发病机制的现有证据。在此过程中，我们试图为一项干预性临床研究提供理论依据，该研究旨在测试补充维生素K是否能延缓慢性肾病患者的血管钙化，甚至影响心血管死亡率。此外，我们希望概述当前文献中关于长期使用维生素K拮抗剂对该人群潜在不良影响的内容。
