Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Department of Nephrology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Int J Mol Sci. 2019 Feb 1;20(3):628. doi: 10.3390/ijms20030628.
Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed.
基质 Gla 蛋白（MGP）是一种小型 Gla 维生素 K 依赖性蛋白，是人体内最强大的天然钙化抑制剂。为了具有生物活性，MGP 必须经历维生素 K 依赖性羧化和磷酸化。维生素 K 缺乏会导致无活性的未羧化、去磷酸化的 MGP（dpucMGP）形式。我们旨在回顾有关循环 dpucMGP 与不同人群中的血管钙化、肾功能、死亡率和心血管疾病之间的关联的现有数据。此外，还回顾了维生素 K 补充与血清 dpucMGP 水平之间的关联。
