无催化剂合成与碘催化相结合：二氢呋喃并嘧啶和螺二氢呋喃并嘧啶吡唑啉酮的一锅法合成
Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones.
作者信息
Zheng Ya-Yun, Feng Kai-Xiang, Xia Ai-Bao, Liu Jie, Tang Cheng-Ke, Zhou Zhan-Yu, Xu Dan-Qian
机构信息
Catalytic Hydrogenation Research Centre, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology Hangzhou 310014 China
出版信息
RSC Adv. 2019 Mar 27;9(17):9770-9776. doi: 10.1039/c9ra01665a. eCollection 2019 Mar 22.
A new and efficient one-pot strategy combining catalyst-free synthesis and iodine catalysis has been developed for the synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones. This approach affords products in moderate to high yields (up to 96%) with excellent diastereoselectivities (up to >25 : 1 dr). The reaction is simple to carry out and is metal-free.
一种结合无催化剂合成和碘催化的新型高效一锅法策略已被开发用于合成二氢呋喃并嘧啶和螺二氢呋喃并嘧啶吡唑啉酮。该方法以中等至高产率（高达96%）提供产物，具有优异的非对映选择性（高达>25:1 dr）。该反应易于进行且无金属。
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