在温和条件下，通过使用2,3-二氧代-4-亚苄基吡咯烷的形式[2 + 1]环加成反应实现螺环丙烷的非对映选择性合成。
Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines.
作者信息
Li Yi, Li Qing-Zhu, Huang Li, Liang Hong, Yang Kai-Chuan, Leng Hai-Jun, Liu Yue, Shen Xu-Dong, Gou Xiao-Jun, Li Jun-Long
机构信息
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China.
出版信息
Molecules. 2017 Feb 22;22(2):328. doi: 10.3390/molecules22020328.
A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.). The asymmetric version of this method was realized by using an easily available chiral sulfur ylide, affording products with moderate to good stereoselectivity.
在无催化剂条件下开发了一种环状烯酮与硫叶立德的高度非对映选择性环丙烷化反应，可生成多官能团螺环丙烷，产率通常很高（高达99%产率且非对映体比例>99:1）。通过使用一种易于获得的手性硫叶立德实现了该方法的不对称版本，得到具有中等至良好立体选择性的产物。
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