Shwartz G, Hill K L, VanBaale M J, Baumgard L H
Department of Animal Sciences, The University of Arizona, Tucson 85721, USA.
J Dairy Sci. 2009 May;92(5):1963-70. doi: 10.3168/jds.2008-1581.
Study objectives were to determine whether a nonsteroidal antiinflammatory drug would reduce parturition-induced inflammation and fever and consequently improve appetite, bioenergetic parameters, and production variables in transitioning dairy cows. Multiparous cows (n = 26) were randomly assigned to 1 of 2 treatments beginning at parturition: 1) flunixin meglumine (FM; 2.2 mg/kg of BW; Banamine, 50 mg/mL, Schering-Plough Animal Health, Kenilworth, NJ), or 2) saline (control) at 2.0 mL/45.5 kg of BW. All treatments were administrated i.v. daily for the first 3 d in milk (DIM). Individual milk yield and dry matter intake (DMI) were recorded daily for the first 35 DIM. Rectal temperature was measured daily at 0700 and 1600 h for the first 7 DIM. Milk composition was determined on 2, 7, 14, 21, 28, and 35 DIM and blood plasma was collected on 1, 2, 3, 4, 7, 14, 21, 28, and 35 DIM. Body weight and body condition score were determined on -7, 1, 7, 14, 21, 28, and 35 DIM. Flunixin meglumine treatment slightly increased rectal temperature (38.99 vs. 38.76 degrees C) during the first 7 DIM and reduced overall DMI (22.04 vs. 19.48 kg/d), but there were no treatment differences in overall milk yield (35.2 kg/d), 3.5% fat-corrected milk (37.6 kg/d), energy-corrected milk (37.7 kg/d), DMI (2.97% of BW), or overall energy balance (-2.32 Mcal/d). There were no treatment differences in milk fat (3.91%), protein (3.32%), or lactose (4.57%). Treatment had no effect on plasma glucose (66.5 mg/dL) or nonesterified fatty acids (553 microEq/L), but plasma urea nitrogen tended to be less in FM-treated cows (16.4 vs. 14.5 mg/dL). Daily FM administration to cows for the first 3 d after parturition slightly increased rectal temperatures by 0.23 degrees C, reduced feed intake, and did not improve production or energetic variables during the first 35 DIM in transition dairy cows.
研究目的是确定一种非甾体抗炎药是否会减轻分娩引起的炎症和发热，从而改善处于围产期的奶牛的食欲、生物能量参数和生产变量。经产奶牛（n = 26）在分娩时被随机分配到两种处理中的一种：1）氟尼辛葡甲胺（FM；2.2 mg/kg体重；Banamine，50 mg/mL，先灵葆雅动物保健公司，新泽西州肯尼沃思），或2）生理盐水（对照），剂量为2.0 mL/45.5 kg体重。所有处理均在产奶的前3天每天静脉注射。在产奶的前35天每天记录个体产奶量和干物质摄入量（DMI）。在产奶的前7天每天0700和1600 h测量直肠温度。在产奶的第2、7、14、21、28和35天测定牛奶成分，并在产奶的第1、2、3、4、7、14、21、28和35天采集血浆。在产奶前-7、1、7、14、21、28和35天测定体重和体况评分。氟尼辛葡甲胺处理在产奶的前7天使直肠温度略有升高（38.99对38.76摄氏度），并降低了总体干物质摄入量（22.04对19.48 kg/天），但在总体产奶量（35.2 kg/天）、3.5%脂肪校正乳（37.6 kg/天）、能量校正乳（37.7 kg/天）、干物质摄入量（体重的2.97%）或总体能量平衡（-2.32 Mcal/天）方面没有处理差异。在乳脂肪（3.91%）、蛋白质（3.32%）或乳糖（4.57%）方面也没有处理差异。处理对血浆葡萄糖（66.5 mg/dL）或非酯化脂肪酸（553 microEq/L）没有影响，但氟尼辛葡甲胺处理的奶牛血浆尿素氮含量倾向于较低（16.4对14.5 mg/dL）。在分娩后的前3天每天给奶牛注射氟尼辛葡甲胺，使直肠温度略有升高0.23摄氏度，减少了采食量，并且在围产期奶牛产奶的前35天没有改善生产或能量变量。
