Makrantonaki Evgenia, Zouboulis Christos C
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
Curr Opin Endocrinol Diabetes Obes. 2009 Jun;16(3):240-5. doi: 10.1097/MED.0b013e32832b71dc.
This study reviews current advances in our understanding of the role of androgens in the initiation of skin ageing.
Skin and its appendages being a steroidogenic tissue itself can be affected to a large extent by sex steroids. Amongst them, androgens display a distinguished role. They modulate epidermal and dermal thickness as proven in a variety of studies measuring gender-specific differences. With advanced age, changes in the circulating androgen levels may alter not only the morphology but also key functions of the skin such as epidermal barrier homeostasis and wound healing, sebaceous gland growth and differentiation and hair growth.
Consequently, skin becomes susceptible to infections and several disease states. Androgen treatment has been proposed to be an effective way to reverse the age-associated deterioration of skin; however, further research is needed to translate current findings to clinically significant diagnostic and therapeutic applications.
本研究综述了目前我们对雄激素在皮肤衰老起始过程中作用的理解进展。
皮肤及其附属器本身就是一个类固醇生成组织，会在很大程度上受到性激素的影响。其中，雄激素发挥着独特作用。在各种测量性别差异的研究中已证实，雄激素可调节表皮和真皮厚度。随着年龄增长，循环雄激素水平的变化不仅可能改变皮肤的形态，还可能改变皮肤的关键功能，如表皮屏障稳态、伤口愈合、皮脂腺生长与分化以及毛发生长。
因此，皮肤变得易受感染和多种疾病状态影响。已提出雄激素治疗是逆转与年龄相关的皮肤退化的有效方法；然而，需要进一步研究将当前发现转化为具有临床意义的诊断和治疗应用。
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