研究鱼子酱油对人类皮肤的抗衰老作用。
Investigating the Anti-Aging Effects of Caviar Oil on Human Skin.
机构信息
Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
出版信息
In Vivo. 2023 Sep-Oct;37(5):2078-2091. doi: 10.21873/invivo.13305.
BACKGROUND/AIM: As the largest organ of the human body, the skin serves as a critical barrier against environmental damage. However, many factors, such as genetics, sun exposure, and lifestyle choices can lead to skin damage creating wrinkles, sagging, and loss of elasticity. The use of skincare products containing natural ingredients has become increasingly popular as a way to combat the signs of aging. Caviar oil is one such ingredient that has gained attention due to its rich composition of fatty acids, vitamins, and minerals. The objective of this study was to investigate the potential anti-aging effects of caviar oil and to develop a product, Cavi Balm, which could potentially reduce wrinkles and skin sagging.
MATERIALS AND METHODS
An in vitro model using the 3T3-L1 cell line was employed to assess the effect of caviar oil on adipocyte differentiation. An ex vivo study using human skin tissue was conducted to investigate the impact of caviar oil on collagen and elastin formation and the expression of matrix metalloproteinase-1,2,9 (MMP-1, MMP-2, MMP-9). Furthermore, 102 participants were enrolled in five clinical studies to evaluate the anti-aging efficacy of our product, "Cavi Balm", in facial and neck wrinkles, facial and eye area lifting, and various skin parameters, such as skin moisture, skin elasticity, skin density, skin tightening relief, skin clarity, and skin turnover.
RESULTS
In vitro, caviar oil enhanced adipocyte differentiation, and increased lipid accumulation inside the cells. The ex vivo analysis revealed that caviar oil reduced the expression levels of MMP-1, MMP-2, and MMP-9, and increased the formation of elastin and collagen I, III. Moreover, in the clinical study, Cavi Balm improved skin parameters after one-time use, with more significant effects observed after four weeks of usage.
CONCLUSION
Caviar oil has a substantial impact on mitigating skin aging and holds potential for application in anti-aging products.
背景/目的：皮肤作为人体最大的器官，是抵御环境损伤的关键屏障。然而，许多因素，如遗传、阳光暴露和生活方式选择，都可能导致皮肤损伤，产生皱纹、松弛和失去弹性。使用含有天然成分的护肤品已成为对抗衰老迹象的一种越来越受欢迎的方法。鱼子酱油就是这样一种成分，由于其富含脂肪酸、维生素和矿物质，因此备受关注。本研究旨在探讨鱼子酱油的潜在抗衰老作用，并开发一种可能减少皱纹和皮肤松弛的产品，即 Cavi Balm。
材料和方法
采用 3T3-L1 细胞系的体外模型评估鱼子酱油对脂肪细胞分化的影响。进行了一项人体皮肤组织的离体研究，以研究鱼子酱油对胶原蛋白和弹性蛋白形成以及基质金属蛋白酶-1、2、9（MMP-1、MMP-2、MMP-9）表达的影响。此外，有 102 名参与者参加了五项临床研究，以评估我们的产品“Cavi Balm”对面部和颈部皱纹、面部和眼部提升以及各种皮肤参数（如皮肤水分、皮肤弹性、皮肤密度、皮肤紧致缓解、皮肤清晰度和皮肤更新）的抗衰老功效。
结果
体外，鱼子酱油增强了脂肪细胞分化，并增加了细胞内的脂质积累。离体分析表明，鱼子酱油降低了 MMP-1、MMP-2 和 MMP-9 的表达水平，增加了弹性蛋白和胶原蛋白 I、III 的形成。此外，在临床研究中，Cavi Balm 在一次使用后改善了皮肤参数，四周后使用效果更为显著。
结论
鱼子酱油对减轻皮肤衰老有显著影响，有望应用于抗衰老产品。
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