Eggermont Alexander M M
Department of Surgical Oncology, Daniel den Hoed Cancer Center, Erasmus University MC, Rotterdam, The Netherlands.
Nat Rev Clin Oncol. 2009 May;6(5):256-8. doi: 10.1038/nrclinonc.2009.42.
The disappointing results of the large, randomized, controlled trials showing no benefit of vaccines in patients with advanced and metastatic melanoma call for a reassessment of the development of therapeutic vaccines and the importance of better immune monitoring methodology, such as adoptive T-cell therapy with lymphodepletion.
大型随机对照试验的结果令人失望，这些试验表明疫苗对晚期和转移性黑色素瘤患者并无益处，这就需要重新评估治疗性疫苗的研发以及更好的免疫监测方法（如采用淋巴细胞清除的过继性T细胞疗法）的重要性。
