Asaduzzaman Sikder M, Sonomoto Kenji
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
J Biosci Bioeng. 2009 May;107(5):475-87. doi: 10.1016/j.jbiosc.2009.01.003.
Lantibiotics are one of the most promising alternative candidates for future antibiotics that maintain their antibacterial efficacy through many mechanisms. Of these mechanisms, some modes of activity have recently been reported, providing opportunities to show these peptides as potential candidates for forthcoming applications. Many findings providing new insight into the detailed molecular activities of numerous lantibiotics are constantly being uncovered. The combination of antibiotic mechanisms in one lantibiotic molecule shows its diverse antimicrobial usefulness as a future generation of antibiotic. Since lantibiotics do not have any known candidate resistance mechanisms, the discovered distinct modes of activity may revolutionize the design of anti-infective drugs through the knowledge provided by these super molecules. In this review, we discuss the rising assortment of lantibiotics, with special emphasis on their structure-function relationships, addressing the unique activities involved in their individual modes of action.
羊毛硫抗生素是未来抗生素中最有前景的替代候选物之一，它们通过多种机制维持抗菌效力。在这些机制中，最近报道了一些作用模式，为将这些肽展示为未来应用的潜在候选物提供了机会。不断有许多发现揭示了羊毛硫抗生素详细分子活性的新见解。一种羊毛硫抗生素分子中抗生素机制的组合显示出其作为下一代抗生素的多样抗菌用途。由于羊毛硫抗生素没有任何已知的耐药机制候选物，所发现的独特作用模式可能通过这些超分子提供的知识彻底改变抗感染药物的设计。在这篇综述中，我们讨论了不断增加的羊毛硫抗生素种类，特别强调它们的结构-功能关系，阐述了其各自作用模式中涉及的独特活性。
