硼中子俘获疗法体外治疗肝转移瘤时用于监测硼分布的快速伽马能谱法：蒙特卡罗模拟研究

Toward prompt gamma spectrometry for monitoring boron distributions during extra corporal treatment of liver metastases by boron neutron capture therapy: a Monte Carlo simulation study.

作者信息

Khelifi R, Nievaart V A, Bode P, Moss R L, Krijger G C

机构信息

LPTHIRM, Department of Physics, Saad Dahlab University, Route de Soumaa, Algeria.

出版信息

Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S359-61. doi: 10.1016/j.apradiso.2009.03.105. Epub 2009 Apr 2.

DOI:10.1016/j.apradiso.2009.03.105

PMID:19394243

Abstract

A Monte Carlo calculation was carried out for boron neutron capture therapy (BNCT) of extra corporal liver phantom. The present paper describes the basis for a subsequent clinical application of the prompt gamma spectroscopy set-up aimed at in vivo monitoring of boron distribution. MCNP code was used first to validate the homogeneity in thermal neutron field in the liver phantom and simulate the gamma ray detection system (collimator and detector) in the treatment room. The gamma ray of 478 keV emitted by boron in small specific region can be detected and a mathematical formalism was used for the tomography image reconstruction.

摘要

对体外肝脏模型的硼中子俘获疗法（BNCT）进行了蒙特卡罗计算。本文描述了用于硼分布体内监测的瞬发伽马能谱装置后续临床应用的基础。首先使用MCNP代码验证肝脏模型中热中子场的均匀性，并模拟治疗室中的伽马射线检测系统（准直器和探测器）。可以检测到硼在小特定区域发射的478 keV伽马射线，并使用数学形式进行断层图像重建。