Guo Zhong-liang, Lu Guo-ping, Ren Tao, Zheng Yong-hua, Gong Jing-yu, Yu Jerry, Liang Yong-jie
Department of Pulmonary Medicine, East Hospital, Tongji University, 150 Jimo road, Pudong New District, Shanghai, China.
Respir Physiol Neurobiol. 2009 Jul 31;167(3):221-6. doi: 10.1016/j.resp.2009.04.015. Epub 2009 Apr 24.
To investigate the effect of partial liquid ventilation (PLV) at low inflation pressures on acute lung injury (ALI), endotoxin was administered to healthy anesthetized juvenile piglets. The animals were randomly assigned to two groups, n=6 each: (1) conventional mechanical ventilation (MV) and (2) PLV with perfluorodecalin (10 mL kg(-1)). Compared with MV, PLV improved each cardiopulmonary variable measured. These variables included pulse contour cardiac output, heart rate, blood pH, breathing rate, both partial pressure of arterial oxygen (PaO2) and PaO2/FIO2 (fraction of inspired oxygen), partial pressure of arterial carbon dioxide (PaCO2), dynamic lung compliance, tidal volume, and ventilation efficacy index. Lung morphology also showed less damage in the PLV group, even in non-dependent regions (P<0.05). Our data support the hypothesis that PLV can decrease pulmonary damage, improve gas exchange and cardiac output, and may lead to a better prognosis in endotoxin-induced ALI.
为研究低充气压力下部分液体通气（PLV）对急性肺损伤（ALI）的影响，将内毒素给予健康的麻醉幼猪。动物被随机分为两组，每组n = 6：（1）传统机械通气（MV）和（2）使用全氟萘烷（10 mL·kg⁻¹）的PLV。与MV相比，PLV改善了所测量的每个心肺变量。这些变量包括脉搏轮廓心输出量、心率、血液pH值、呼吸频率、动脉血氧分压（PaO₂）和PaO₂/FIO₂（吸入氧分数）、动脉血二氧化碳分压（PaCO₂）、动态肺顺应性、潮气量和通气效能指数。肺形态学显示PLV组的损伤也较小，即使在非依赖区域也是如此（P<0.05）。我们的数据支持这样的假设，即PLV可减少肺部损伤，改善气体交换和心输出量，并可能导致内毒素诱导的ALI有更好的预后。
