Pediatric Heart Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Chin Med J (Engl). 2012 Jan;125(1):123-8.
Pediatric patients are susceptible to lung injury. Acute lung injury in children often results in high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor (TNF)-α in an immature piglet model of acute lung injury induced by oleic acid (OA).
Twelve Chinese immature piglets were induced acute lung injury by OA. The animals were randomly assigned to two groups of six animals, (1) conventional mechanical ventilation (MV) group and (2) PLV with 10 ml/kg FC-77 group.
Compared with MV group, the PLV group had better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/inspired O2 fraction (FiO2) and partial pressure of arterial carbon dioxide (PaCO2). PLV reduced TNF-α levels both in plasma and tissue compared with MV group (P < 0.05).
PLV provides protective effects against TNF-α response in OA-induced acute lung injury in immature piglets.
儿科患者易发生肺损伤。儿童急性肺损伤常导致高死亡率。部分液体通气（PLV）已被证明在多种肺损伤模型中明显改善氧合并减少组织学损伤证据。本研究旨在检验以下假设，即 PLV 可减轻油酸（OA）诱导的未成熟猪急性肺损伤模型中局部和全身肿瘤坏死因子（TNF）-α的产生。
12 只中国未成熟仔猪通过 OA 诱导急性肺损伤。动物随机分为两组，每组 6 只动物，（1）常规机械通气（MV）组和（2）PLV 用 10 ml/kg FC-77 组。
与 MV 组相比，PLV 组心肺变量更好（P < 0.05）。这些变量包括心率、平均血压、血液 pH 值、动脉血氧分压（PaO2）、PaO2/吸入氧分数（FiO2）和动脉二氧化碳分压（PaCO2）。PLV 降低了与 MV 组相比，血浆和组织中的 TNF-α 水平（P < 0.05）。
PLV 对油酸诱导的未成熟猪急性肺损伤中 TNF-α 反应具有保护作用。
