携带肿瘤小鼠体内TF-PEG-脂质体-硼替佐米的分布情况。
Disposition of TF-PEG-Liposome-BSH in tumor-bearing mice.
作者信息
Ito Y, Kimura Y, Shimahara T, Ariyoshi Y, Shimahara M, Miyatake S, Kawabata S, Kasaoka S, Ono K
机构信息
Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Osaka Medical College, Japan.
出版信息
Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S109-10. doi: 10.1016/j.apradiso.2009.03.018. Epub 2009 Mar 26.
BNCT requires high concentration and selective delivery of (10)B to the tumor cell. To improve the drug delivery in BNCT, we conducted a study by devising TPLB. We administrated three types of boron delivery systems: BSH, PLB and TPLB, to Oral SCC bearing mice. Results confirmed that (10)B concentration is higher in the TPLB group than in the BSH group and that TPLB is significantly effective as boron delivery system.
硼中子俘获疗法（BNCT）需要将硼 - 10（¹⁰B）高浓度且选择性地递送至肿瘤细胞。为了改善BNCT中的药物递送，我们通过设计三苯基膦硼酸酯（TPLB）进行了一项研究。我们给患有口腔鳞状细胞癌的小鼠施用了三种硼递送系统：硼氢化钠（BSH）、磷脂硼（PLB）和TPLB。结果证实，TPLB组中的硼 - 10浓度高于BSH组，并且TPLB作为硼递送系统具有显著效果。
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