当前肿瘤靶向脂质体应用的趋势。
Current trends in the use of liposomes for tumor targeting.
机构信息
Center for Pharmaceutical Biotechnology & Nanomedicine, 360 Huntington Avenue, 140 The Fenway, Northeastern University, Boston, MA 02115, USA.
出版信息
Nanomedicine (Lond). 2013 Sep;8(9):1509-28. doi: 10.2217/nnm.13.118.
Abstract
The use of liposomes for drug delivery began early in the history of pharmaceutical nanocarriers. These nanosized, lipid bilayered vesicles have become popular as drug delivery systems owing to their efficiency, biocompatibility, nonimmunogenicity, enhanced solubility of chemotherapeutic agents and their ability to encapsulate a wide array of drugs. Passive and ligand-mediated active targeting promote tumor specificity with diminished adverse off-target effects. The current field of liposomes focuses on both clinical and diagnostic applications. Recent efforts have concentrated on the development of multifunctional liposomes that target cells and cellular organelles with a single delivery system. This review discusses the recent advances in liposome research in tumor targeting.
摘要
脂质体作为药物传递载体的应用始于药物纳米载体的早期历史。这些纳米大小的、双层脂质体囊泡因其高效、生物相容性、非免疫原性、增加化疗药物的溶解度以及能够包裹各种药物的能力，已成为受欢迎的药物传递系统。被动和配体介导的主动靶向作用促进了肿瘤的特异性，减少了不良反应的发生。目前脂质体领域的研究重点是临床和诊断应用。最近的研究集中在开发多功能脂质体上，这些脂质体可以用单一的递药系统靶向细胞和细胞细胞器。本文综述了肿瘤靶向脂质体研究的最新进展。
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本文引用的文献
1
Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting.用于增强肿瘤靶向性的多功能脂质体纳米载体的最新趋势。
J Drug Deliv. 2013;2013:705265. doi: 10.1155/2013/705265. Epub 2013 Mar 7.
2
Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility.介孔硅纳米颗粒纳米载体：生物功能和生物相容性。
Acc Chem Res. 2013 Mar 19;46(3):792-801. doi: 10.1021/ar3000986. Epub 2013 Feb 6.
3
Surface functionalization of doxorubicin-loaded liposomes with octa-arginine for enhanced anticancer activity.载多柔比星脂质体的表面八精氨酸功能化以增强抗癌活性。
Eur J Pharm Biopharm. 2013 Aug;84(3):517-25. doi: 10.1016/j.ejpb.2012.12.021. Epub 2013 Jan 17.
4
Hyperthermia-induced drug targeting.热诱导药物靶向。
Expert Opin Drug Deliv. 2013 Apr;10(4):511-27. doi: 10.1517/17425247.2013.758631. Epub 2013 Jan 7.
5
Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine.玛尔奎伯（硫酸长春新碱脂质体注射液）改善了长春新碱的药代动力学和药效学。
Cancer Chemother Pharmacol. 2013 Mar;71(3):555-64. doi: 10.1007/s00280-012-2042-4. Epub 2012 Dec 5.
6
Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.基于超顺磁性氧化铁纳米颗粒的生物治疗递送系统。
Expert Opin Drug Deliv. 2013 Jan;10(1):73-87. doi: 10.1517/17425247.2013.747507. Epub 2012 Dec 1.
7
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