甲泼尼龙在诱导大鼠卡氏肺孢子虫感染方面优于地塞米松。
Superiority of methylprednisolone over dexamethasone for induction of Pneumocystis carinii infection in rats.
作者信息
Sukura A, Soveri T, Lindberg L A
机构信息
Department of Anatomy, College of Veterinary Medicine, Helsinki, Finland.
出版信息
J Clin Microbiol. 1991 Oct;29(10):2331-2. doi: 10.1128/jcm.29.10.2331-2332.1991.
Abstract
Because of difficulties in in vitro cultivation, the basic Pneumocystis carinii studies have been carried out on animal models, mainly on rodents immunosuppressed by corticosteroids. Commonly used dexamethasone and methylprednisolone procedures were evaluated. The intensity of infection in rats was statistically significantly higher after 9 weeks' immunosuppression with methylprednisolone than with dexamethasone.
摘要
由于体外培养存在困难，卡氏肺孢子虫的基础研究是在动物模型上进行的，主要是在接受皮质类固醇免疫抑制的啮齿动物身上。对常用的地塞米松和甲泼尼龙程序进行了评估。用甲泼尼龙进行9周免疫抑制后，大鼠的感染强度在统计学上显著高于用地塞米松免疫抑制的大鼠。
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本文引用的文献
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