无菌大鼠发生卡氏肺孢子虫肺炎需要免疫抑制以及接触卡氏肺孢子虫病原体。
The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism.
作者信息
Wolff L, Horch S, Gemsa D
机构信息
Institute for Immunology, Philipps University, Marburg, Germany.
出版信息
Comp Immunol Microbiol Infect Dis. 1993 Jan;16(1):73-6. doi: 10.1016/0147-9571(93)90063-b.
PMID:8440087
Abstract
Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.
摘要
用 dexamethasone 处理并暴露于非无菌环境的成年无菌大鼠，在免疫抑制 10 周后未携带或出现卡氏肺孢子虫囊肿或滋养体。只有当它们暴露于受感染的普通大鼠并接受 dexamethasone 处理 8 周或更长时间时，成年无菌大鼠才会发生卡氏肺孢子虫感染。
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