K3[VO(O2)2CO3]∙H2O 的光谱行为和生物活性。

Spectroscopic behavior and biological activity of K3[VO(O2)2CO3]∙H2O.

机构信息

Química Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de República, Montevideo, Uruguay.

出版信息

Biol Trace Elem Res. 2009 Dec;132(1-3):176-83. doi: 10.1007/s12011-009-8375-0.

DOI:10.1007/s12011-009-8375-0

PMID:19396406

Abstract

The potassium salt of the carbonato oxodiperoxovanadate(V) complex, obtained by a known synthetic procedure, was thoroughly characterized by infrared, Raman, and electronic spectroscopy. The bioactivity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. At low doses, the complex is more toxic for the nontransformed osteoblasts than for the tumoral ones, whereas at higher doses the deleterious effects are similar for both cell lines. This peroxo complex seems to be the most toxic compound that has so far been tested on osteoblast-like cells in culture.

摘要

通过已知的合成程序获得的碳酸氧二过氧钒(V)配合物的钾盐通过红外、拉曼和电子光谱法进行了彻底的表征。在培养的成骨样细胞（MC3T3E1 成骨细胞样小鼠颅骨衍生细胞和 UMR106 大鼠骨肉瘤衍生细胞）上测试了该配合物对细胞增殖的生物活性。在低剂量下，该配合物对未转化的成骨细胞比对肿瘤细胞的毒性更大，而在高剂量下，两种细胞系的有害作用相似。这种过氧配合物似乎是迄今为止在培养的成骨样细胞上测试过的最毒化合物。