Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Biol Trace Elem Res. 2012 Jun;147(1-3):403-7. doi: 10.1007/s12011-012-9322-z. Epub 2012 Jan 13.
The oxovanadium(IV) complex of oxodiacetic acid (H(2)ODA) and o-phenanthroline of stoichiometry [VO(ODA)(ophen)]·1.5H(2)O, which presents the interesting tridentate OOO coordination, was thoroughly characterized by infrared, Raman, and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast cell lines in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts.
标题
奥沙沃丹（IV）配合物氧二乙酸（H（2）ODA）和邻菲咯啉的化学计量学[VO（ODA）（ophen）]·1.5H（2）O，呈现出有趣的三齿 OOO 配位，通过红外，拉曼和电子光谱学进行了彻底的表征。在培养的成骨细胞（MC3T3E1 成骨细胞样细胞和 UMR106 大鼠骨肉瘤衍生细胞）上测试了该配合物对细胞增殖的生物活性。该配合物在两种成骨细胞系的培养中均引起细胞增殖的抑制，但在正常（MC3T3E1）细胞中比在肿瘤（UMR106）成骨细胞中的细胞毒性更强。
