Department of Physiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
Biol Trace Elem Res. 2009 Dec;132(1-3):153-63. doi: 10.1007/s12011-009-8372-3.
The levels of blood lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamin C were used to follow the level of oxidative damage caused by 2.45 GHz electromagnetic radiation in rats. The possible protective effects of selenium and L-carnitine were also tested and compared to untreated controls. Thirty male Wistar Albino rats were equally divided into five groups, namely Groups A1 and A2: controls and sham controls, respectively; Group B: EMR; Group C: EMR + selenium, Group D: EMR + L-carnitine. Groups B–D were exposed to 2.45 GHz electromagnetic radiation during 60 min/ day for 28 days. The lipid peroxidation levels in plasma and erythrocytes were significantly higher in group B than in groups A1 and A2 (p<0.05), although the reduced glutathione and glutathione peroxidase values were slightly lower in erythrocytes of group B compared to groups A1 and A2. The plasma lipid peroxidation level in group A2 was significantly lower than in group B (p<0.05). Erythrocyte reduced glutathione levels (p<0.01) in group B; erythrocyte glutathione peroxidase activity in group A2 (p<0.05), group B (p<0.001), and group C (p<0.05) were found to be lower than in group D. In conclusion, 2.45 GHz electromagnetic radiation caused oxidative stress in blood of rat. L-carnitine seems to have protective effects on the 2.45-GHz-induced blood toxicity by inhibiting free radical supporting antioxidant redox system although selenium has no effect on the investigated values.
采用测定脂质过氧化水平、谷胱甘肽过氧化物酶、还原型谷胱甘肽和维生素 C 水平的方法，观察 2.45GHz 电磁辐射对大鼠氧化损伤的作用，并与硒和左旋肉碱的可能保护作用进行了对比。将 30 只雄性 Wistar 白化大鼠等分为 5 组，即 A1 组和 A2 组（分别为对照组和假照射对照组）、B 组（单纯照射组）、C 组（照射加硒组）、D 组（照射加左旋肉碱组）。B-D 组大鼠连续 28 天每天接受 2.45GHz 电磁辐射 60min。与 A1 组和 A2 组相比，B 组大鼠血浆和红细胞的脂质过氧化水平明显升高（p<0.05），而 B 组大鼠红细胞的还原型谷胱甘肽和谷胱甘肽过氧化物酶值略低于 A1 组和 A2 组。与 B 组相比，A2 组大鼠血浆的脂质过氧化水平明显较低（p<0.05）。B 组大鼠红细胞的还原型谷胱甘肽水平显著降低（p<0.01），A2 组大鼠红细胞的谷胱甘肽过氧化物酶活性、B 组（p<0.001）和 C 组（p<0.05）均显著降低。结论：2.45GHz 电磁辐射可引起大鼠血液氧化应激。左旋肉碱可能通过抑制自由基支持的抗氧化还原系统对 2.45GHz 诱导的血液毒性具有保护作用，而硒对所研究的各项指标均无影响。
