Shaikh Faisal M, Naqvi Syed A, Grace Pierce A
Department of Surgery, Mid-Western Regional Hospital, Limerick, Ireland.
Dermatol Surg. 2009 Jun;35(6):948-51. doi: 10.1111/j.1524-4725.2009.01160.x. Epub 2009 Apr 8.
A eutectic mixture of lidocaine and prilocaine (EMLA) has been shown to be effective in reducing pain from needle sticks, including those associated with blood sampling and intravenous insertion.
To evaluate the effectiveness of EMLA cream applied before needle puncture for local anesthetic administration before minor surgical procedures in this double-blind, randomized, controlled, parallel-group study.
Patients were randomly assigned to receive EMLA or placebo cream (Aqueous) applied under an occlusive dressing. After the procedure, patients were asked to rate the needle prick and procedure pain on a visual analog scale (0=no pain; 10=maximum pain).
A total of 94 minor surgical procedures (49 in EMLA and 45 in control) were performed. The mean needle-stick pain score in the EMLA group was significantly lower than in the control group (2.7 vs. 5.7, p<.001, Mann-Whitney U-test). There was also significantly lower procedure pain in the EMLA group than in the control group (0.83 vs. 1.86, p=.009). There were no complications associated with the use of EMLA.
EMLA effectively reduces the preprocedural needle-stick pain and procedural pain associated with minor surgical procedures.
利多卡因和丙胺卡因的共熔混合物（EMLA）已被证明能有效减轻针刺疼痛，包括与采血和静脉穿刺相关的疼痛。
在这项双盲、随机、对照、平行组研究中，评估在小手术前穿刺前涂抹EMLA乳膏用于局部麻醉的有效性。
患者被随机分配接受在封闭敷料下涂抹EMLA或安慰剂乳膏（水性）。术后，要求患者用视觉模拟评分法（0=无疼痛；10=最大疼痛）对针刺和手术疼痛进行评分。
共进行了94例小手术（EMLA组49例，对照组45例）。EMLA组的平均针刺疼痛评分显著低于对照组（2.7对5.7，p<0.001，曼-惠特尼U检验）。EMLA组的手术疼痛也显著低于对照组（0.83对1.86，p=0.009）。使用EMLA没有相关并发症。
EMLA能有效减轻与小手术相关的术前针刺疼痛和手术疼痛。
