Neuhaus Isaac M, Zane Lee T, Tope Whitney D
Dermatologic Surgery and Laser Center, Department of Dermatology, University of California, San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA.
Dermatol Surg. 2009 Jun;35(6):920-8. doi: 10.1111/j.1524-4725.2009.01156.x. Epub 2009 Apr 6.
Erythematotelangiectatic (ET) rosacea is commonly treated with a variety of laser and light-based systems. Although many have been used successfully, there are a limited number of comparative efficacy studies.
To compare nonpurpuragenic pulsed dye laser (PDL) with intense pulsed light (IPL) treatment in the ability to reduce erythema, telangiectasia, and symptoms in patients with moderate facial ET rosacea.
Twenty-nine patients were enrolled in a randomized, controlled, single-blind, split-face trial with nonpurpuragenic treatment with PDL and IPL and untreated control. Three monthly treatment sessions were performed with initial PDL settings of 10-mm spot size, 7 J/cm(2), 6-ms pulse duration and cryogen cooling, and initial IPL settings of 560-nm filter, a pulse train of 2.4 and 6.0 ms in duration separated by a 15-ms delay, and a starting fluence of 25 J/cm(2). Evaluation measures included spectrophotometric erythema scores, blinded investigator grading, and patient assessment of severity and associated symptoms.
PDL and IPL resulted in significant reduction in cutaneous erythema, telangiectasia, and patient-reported associated symptoms. No significant difference was noted between PDL and IPL treatment.
A series of nonpurpuragenic PDL and IPL treatments in ET rosacea was performed with similar efficacy and safety, and both modalities seem to be reasonable choices for the treatment of ET rosacea.
红斑毛细血管扩张型（ET）酒渣鼻通常采用多种基于激光和光的系统进行治疗。尽管许多方法已成功应用，但比较疗效的研究数量有限。
比较非紫癜性脉冲染料激光（PDL）与强脉冲光（IPL）治疗中度面部ET酒渣鼻患者在减轻红斑、毛细血管扩张和症状方面的能力。
29例患者参与了一项随机、对照、单盲、面部双侧对照试验，分别接受非紫癜性PDL和IPL治疗以及不治疗对照。每月进行3次治疗，PDL初始设置为光斑大小10mm、能量密度7J/cm²、脉冲持续时间6ms及冷冻剂冷却，IPL初始设置为560nm滤光片、脉冲序列持续时间为2.4ms和6.0ms，间隔15ms延迟，起始能量密度为25J/cm²。评估指标包括分光光度法红斑评分、盲法研究者分级以及患者对严重程度和相关症状的评估。
PDL和IPL均显著减轻了皮肤红斑、毛细血管扩张以及患者报告的相关症状。PDL和IPL治疗之间未发现显著差异。
对ET酒渣鼻进行一系列非紫癜性PDL和IPL治疗，疗效和安全性相似，两种方式似乎都是治疗ET酒渣鼻的合理选择。
