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强脉冲光治疗痤疮后炎症性红斑

Intense Pulsed Light Therapy for Acne-induced Post-inflammatory Erythema.

作者信息

Mathew Minu L, Karthik R, Mallikarjun M, Bhute Soumya, Varghese Aiswarya

机构信息

Department of Dermatology, Venereology and Leprosy, K.V.G Medical College and Hospital, Sullia, Karnataka, India.

出版信息

Indian Dermatol Online J. 2018 May-Jun;9(3):159-164. doi: 10.4103/idoj.IDOJ_306_17.

Abstract

BACKGROUND

Intense pulsed light (IPL) is a comparatively new system of practice in treating acne-induced post inflammatory erythema (PIE) which is a difficult condition to treat, and variations exist in the results from published studies with insufficient or limited scientific evidence of IPL on Indian skin.

AIM

To study the efficacy of IPL in the treatment of acne-induced PIE and to document adverse effects of the procedure.

SETTINGS AND DESIGN

A hospital-based retrospective observational study on 33 patients with acne-induced PIE who completed treatment with IPL during the time period of July 2015 to June 2017.

PATIENTS AND METHODS

All 33 patients were treated with vascular mode of IPL using 560-nm filter every 3 weeks for three to six sessions. Grading of PIE was done by Clinician Erythema Severity Score, and the objective parameters were assessed statistically for improvement using photographs. Adverse effects were noted and followed up.

STATISTICAL ANALYSIS

Wilcoxon sign rank test and Pearson's correlation.

RESULTS

There was statistically significant reduction in mean erythema score from 2.57 ± 0.66 to 1.21 ± 0.48 following IPL ( = -5.295, < 0.001-Wilcoxon sign rank test). Excellent improvement was noted in 11 (33.33%), good in 15 (45.45%), fair in 4 (12.12%), and poor in 3 (9.09%), and the results were consistent on follow-up. Adverse effects included erythema, hyperpigmentation, and hypopigmentation which were all transient and resolved completely in all patients on follow-up.

CONCLUSION

IPL is an effective and safe alternative to otherwise difficult-to-treat acne-induced PIE.

摘要

背景

强脉冲光(IPL)是治疗痤疮后炎症性红斑(PIE)的一种相对较新的治疗方法,而痤疮后炎症性红斑是一种难以治疗的病症,已发表的研究结果存在差异,且关于IPL对印度皮肤的研究证据不足或有限。

目的

研究强脉冲光治疗痤疮后炎症性红斑的疗效,并记录该治疗方法的不良反应。

设置与设计

一项基于医院的回顾性观察研究,研究对象为33例痤疮后炎症性红斑患者,这些患者于2015年7月至2017年6月期间完成了强脉冲光治疗。

患者与方法

所有33例患者均采用560纳米滤光片的强脉冲光血管模式进行治疗,每3周治疗一次,共治疗三至六次。采用临床医生红斑严重程度评分对炎症性红斑进行分级,并通过照片对客观参数进行统计学评估以观察改善情况。记录并随访不良反应。

统计分析

采用Wilcoxon符号秩检验和Pearson相关性分析。

结果

强脉冲光治疗后,平均红斑评分从2.57±0.66显著降至1.21±0.48(Z=-5.295,P<0.001-Wilcoxon符号秩检验)。11例(33.33%)改善极佳,15例(45.45%)改善良好,4例(12.12%)改善一般,3例(9.09%)改善较差,随访结果一致。不良反应包括红斑、色素沉着和色素减退,均为暂时性,所有患者随访时均完全消退。

结论

对于难以治疗的痤疮后炎症性红斑,强脉冲光是一种有效且安全的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2f/5956861/e4244e716216/IDOJ-9-159-g003.jpg

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