瞬时受体电位香草酸亚型1信号通路抑制人树突状细胞的分化和激活。
Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells.
作者信息
Tóth Balázs I, Benko Szilvia, Szöllosi Attila G, Kovács László, Rajnavölgyi Eva, Bíró Tamás
机构信息
Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary.
出版信息
FEBS Lett. 2009 May 19;583(10):1619-24. doi: 10.1016/j.febslet.2009.04.031. Epub 2009 May 4.
The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions.
本研究的目的是调查瞬时受体电位香草酸亚型1（TRPV1）在人体外分化的单核细胞衍生树突状细胞（DCs）上的表达，并剖析TRPV1信号在DC特异性功能中的相应作用。在人DCs中，在蛋白质和基因水平均鉴定出TRPV1表达。此外，典型的TRPV1激动剂辣椒素特异性地（即通过TRPV1）并呈剂量依赖性地抑制细胞因子诱导的DC分化、细菌吞噬作用、DC激活以及促炎细胞因子分泌。这些数据表明TRPV1偶联信号作为人类单核细胞衍生DC生物学中具有抗炎作用的新参与者。
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