Institute of Health & Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.
PLoS Negl Trop Dis. 2009;3(4):e423. doi: 10.1371/journal.pntd.0000423. Epub 2009 Apr 28.
Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975.
登革病毒在人和丛林循环中传播。虽然感染人类的登革病毒（DENV）可能引发重大疫情和严重疾病，但对丛林登革病毒的流行病学和病因学了解相对较少。2008 年 1 月，一名 20 岁男性在马来西亚出现登革出血热（DHF）伴血小板减少症（12,000/μl）和血细胞比容升高（比基线高 29.5%）。第 4 天发热时从其血液中分离出血清型 2 型登革病毒。对全基因组序列的系统发育分析表明，该病毒属于 DENV-2 的丛林谱系成员，与 1970 年从马来西亚的哨兵猴中分离出的病毒最为密切相关。这是自 1975 年以来首次在亚洲发现循环的丛林型 DENV。
