一起与被污染的台盼蓝眼科溶液相关的术后革兰氏阴性细菌性眼内炎暴发。
An outbreak of postoperative gram-negative bacterial endophthalmitis associated with contaminated trypan blue ophthalmic solution.
作者信息
Sunenshine Rebecca, Schultz Maureen, Lawrence Mary G, Shin Soo, Jensen Bette, Zubairi Sabiha, Labriola Ann M, Shams Alicia, Noble-Wang Judith, Arduino Matthew J, Gordin Fred, Srinivasan Arjun
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Clin Infect Dis. 2009 Jun 1;48(11):1580-3. doi: 10.1086/598938.
We report 6 cases of postsurgical endophthalmitis due to gram-negative bacteria associated with contaminated trypan blue dye from a compounding pharmacy. Unopened trypan blue syringes yielded Pseudomonas aeruginosa and Burkholderia cepacia complex on culture, with pulsed-field gel electrophoresis patterns indistinguishable from patient isolates. Contamination of compounded medications should be considered when investigating outbreaks of postoperative endophthalmitis.
我们报告了6例因来自一家配制药房的被污染台盼蓝染料导致的革兰氏阴性菌引起的术后眼内炎病例。未开封的台盼蓝注射器在培养时产生了铜绿假单胞菌和洋葱伯克霍尔德菌复合体，其脉冲场凝胶电泳图谱与患者分离株无法区分。在调查术后眼内炎暴发时，应考虑复合药物的污染情况。
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