Orhan F, Karakas T, Cakir M, Aksoy A, Baki A, Gedik Y
Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Clin Exp Allergy. 2009 Jul;39(7):1027-35. doi: 10.1111/j.1365-2222.2009.03263.x. Epub 2009 Apr 27.
The prevalence of adverse reactions to food in childhood in Turkey is not known.
We aimed to investigate the prevalence and characteristics of IgE-mediated food allergies (FAs) in 6-9-year-old urban schoolchildren.
This cross-sectional study recruited 3500 of the randomly selected 6-9-year-old urban schoolchildren from the eastern Black Sea region of Turkey during 2006. Following a self-administered questionnaire completed by the parents and the child, consenting children were invited for skin prick tests (SPTs) and oral food challenges. Children with suspected IgE-mediated FA were skin prick tested with a predefined panel of food allergens (milk, hen's egg, soy, wheat, peanut, fish, and hazelnut), aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, Alternaria, grass pollen mix, weed pollen mix, and tree pollen mix), and food allergens reported in the questionnaire. All children with a positive SPT to any food were invited for a double-blind, placebo-controlled food challenge (DBPCFC). The prevalence of IgE-mediated FA was established using DBPCFCs.
The response rate to the questionnaire was 78.2% (2739/3500). The estimated prevalence of parental-reported IgE-mediated FA was 5.7% (156/2739) [95% confidence interval (CI), 4.83-6.57%]. The rate of sensitization to the food allergens was 33.1% (48/145) in the parental-reported group. The confirmed prevalence of IgE-mediated FA by means of DBPCFC in 6-9-year-old urban schoolchildren living in the eastern Black Sea region of Turkey was 0.80% (22/2739) (95% CI, 0.47-1.13%). The most common allergenic foods were beef (31.8%), cow's milk (18.1%), cocoa (18.1%), hen's egg (13.6%), and kiwi (13.6%).
The rate of reported IgE-mediated FA was significantly higher than clinically confirmed FA by means of DBPCFC (odds ratio, 7.46; 95% CI, 4.67-12.01; P<0.0001). The order of allergenic foods was different and somewhat unique to the eastern Black Sea region of Turkey when compared with western countries.
土耳其儿童食物不良反应的患病率尚不清楚。
我们旨在调查6至9岁城市学童中IgE介导的食物过敏（FA）的患病率及特征。
这项横断面研究于2006年从土耳其黑海东部地区随机选取了3500名6至9岁的城市学童。在家长和孩子完成一份自填式问卷后，同意参与的儿童被邀请进行皮肤点刺试验（SPT）和口服食物激发试验。对疑似IgE介导的FA的儿童，用一组预先定义的食物过敏原（牛奶、鸡蛋、大豆、小麦、花生、鱼和榛子）、气传过敏原（屋尘螨、粉尘螨、猫、狗、链格孢属、混合草花粉、混合杂草花粉和混合树花粉）以及问卷中报告的食物过敏原进行皮肤点刺试验。所有皮肤点刺试验对任何食物呈阳性的儿童均被邀请进行双盲、安慰剂对照食物激发试验（DBPCFC）。通过DBPCFC确定IgE介导的FA的患病率。
问卷的回复率为78.2%（2739/3500）。父母报告的IgE介导的FA的估计患病率为5.7%（156/2739）[95%置信区间（CI），4.83 - 6.57%]。在父母报告的组中，对食物过敏原的致敏率为33.1%（48/145）。在土耳其黑海东部地区居住的6至9岁城市学童中，通过DBPCFC确诊的IgE介导的FA的患病率为0.80%（22/2739）（95%CI，0.47 - 1.13%）。最常见的致敏食物是牛肉（31.8%）、牛奶（18.1%）、可可（18.1%）、鸡蛋（13.6%）和猕猴桃（13.6%）。
报告的IgE介导的FA的发生率显著高于通过DBPCFC临床确诊的FA（优势比，7.46；95%CI，4.67 - 12.01；P<0.0001）。与西方国家相比，致敏食物的顺序有所不同，且在土耳其黑海东部地区 somewhat unique（此处原文有误，推测为“ somewhat unique”，意为“有些独特”）。
