重新审视癌症转移中的“种子与土壤”学说
Revisiting the seed and soil in cancer metastasis.
作者信息
Mendoza Martin, Khanna Chand
机构信息
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.
出版信息
Int J Biochem Cell Biol. 2009 Jul;41(7):1452-62. doi: 10.1016/j.biocel.2009.01.015. Epub 2009 Feb 3.
Abstract
Metastasis remains the overwhelming cause of death for cancer patients. During metastasis, cancer cells will leave the primary tumor, intravasate into the bloodstream, arrest at a distant organ, and eventually develop into gross lesions at the secondary sites. This intricate process is influenced by innumerable factors and complex cellular interactions described in 1889 by Stephen Paget as the seed and soil hypothesis. In this review, we revisit this seed and soil hypothesis with an emerging understanding of the cancer cell (i.e. seed) and its microenvironment (i.e. soil). We will provide background to suggest that a critical outcome of the seed-soil interaction is resistance of the stresses that would otherwise impede metastasis.
摘要
转移仍然是癌症患者死亡的主要原因。在转移过程中，癌细胞会离开原发肿瘤，侵入血液循环，在远处器官滞留，并最终在继发部位发展为肉眼可见的病变。这一复杂过程受到无数因素以及复杂细胞相互作用的影响，斯蒂芬·佩吉特在1889年将其描述为种子与土壤假说。在本综述中，我们结合对癌细胞（即种子）及其微环境（即土壤）的新认识，重新审视这一种子与土壤假说。我们将提供背景信息，以表明种子与土壤相互作用的一个关键结果是对原本会阻碍转移的应激具有抗性。
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