Herr Andrew B, Farndale Richard W
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0524, USA.
J Biol Chem. 2009 Jul 24;284(30):19781-5. doi: 10.1074/jbc.R109.013219. Epub 2009 Apr 28.
Collagen peptides have been used to identify binding sites for several important collagen receptors, including integrin alpha(2)beta(1), glycoprotein VI, and von Willebrand factor. In parallel, the structures of these collagen receptors have been reported, and their interactions with collagen peptides have been studied. Recently, the three-dimensional structure of the intact type I collagen fiber from rat tail tendon has been resolved by fiber diffraction. It is now possible to map the binding sites of platelet collagen receptors onto the intact collagen fiber in three dimensions. This minireview will discuss these recent findings and their implications for platelet activation by collagen.
胶原蛋白肽已被用于识别几种重要的胶原蛋白受体的结合位点，包括整合素α(2)β(1)、糖蛋白VI和血管性血友病因子。与此同时，这些胶原蛋白受体的结构也已被报道，并且它们与胶原蛋白肽的相互作用也已得到研究。最近，通过纤维衍射解析了来自大鼠尾腱的完整I型胶原纤维的三维结构。现在有可能在三维空间中将血小板胶原蛋白受体的结合位点映射到完整的胶原纤维上。这篇综述将讨论这些最新发现及其对胶原蛋白诱导血小板激活的意义。
