前列腺癌来源的尿液外泌体：一种用于前列腺癌生物标志物的新方法。
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.
作者信息
Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva-Nilsson L, Breakefield X O, Widmark A
机构信息
Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden.
出版信息
Br J Cancer. 2009 May 19;100(10):1603-7. doi: 10.1038/sj.bjc.6605058. Epub 2009 Apr 28.
Abstract
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
摘要
在此，我们描述了一种寻找前列腺癌生物标志物的新方法，该方法依赖于肿瘤外泌体中的转录组。作为概念验证，我们在从患者尿液中分离出的外泌体中发现了两种已知的前列腺癌生物标志物，即PCA-3和TMPRSS2:ERG，这显示了诊断和监测癌症患者状态的潜力。
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